The overuse of antibiotics has led to the emergence of a large number of antibiotic-resistant
genes in bacteria, and increasing evidence indicates that a fungicide with an antibacterial …

Bacterial biofilms formed by pathogens are known to be hundreds of times more resistant to
antimicrobial agents than planktonic cells, making it extremely difficult to cure biofilm-based …

Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

Endolysin-based therapeutics are promising antibacterial agents and can successfully
supplement the existing antibacterial drugs array. It is specifically important in the case of …

Bacteriophage-encoded depolymerases are responsible for degrading capsular
polysaccharides (CPS), lipopolysaccharides (LPS), and exopolysaccharides (EPS) of the …

Highlights●Phage endolysins are promising alternative antimicrobials.●The Gram-
negative outer membrane prevents exogenous activity of most endolysins.●Three features …

Antimicrobial peptides (AMPs) are one of the elements of innate immunity that have a crucial
role in fighting infections. These molecules are produced by all kinds of cells and can …

Most clinical isolates of Acinetobacter baumannii, a nosocomial pathogen, are multidrug-
resistant (MDR), fueling the search for alternative therapies. Bacteriophage-derived …

Direct lytic agents (DLAs) are novel antimicrobial compounds with unique mechanisms of
action based on rapid cell wall destabilization and bacteriolysis. DLAs include two classes of …