Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …

Despite tremendous progress in the past decade, the complex and heterogeneous nature of
cancer complicates efforts to identify new therapies and therapeutic combinations that …

Understanding protein function and developing molecular therapies require deciphering the
cell types in which proteins act as well as the interactions between proteins. However …

Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …

A central goal of genetics is to define the relationships between genotypes and phenotypes.
High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single …

Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …

Summary RNA polymerase II (RNAPII) controls expression of all protein-coding genes and
most noncoding loci in higher eukaryotes. Calibrating RNAPII activity requires an assortment …

The DNA damage response (DDR) ensures error-free DNA replication and transcription and
is disrupted in numerous diseases. An ongoing challenge is to determine the proteins …

Despite advances in precision medicine, the clinical prospects for patients with ovarian and
uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR …