Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible
for the metabolism of about 60% of currently known drugs. However, this unusual low …
for the metabolism of about 60% of currently known drugs. However, this unusual low …
High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery
RE White - Annual review of pharmacology and toxicology, 2000 - annualreviews.org
The application of rapid methods currently used for screening discovery drug candidates for
metabolism and pharmacokinetic characteristics is discussed. General considerations are …
metabolism and pharmacokinetic characteristics is discussed. General considerations are …
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
PA Williams, J Cosme, DM Vinkovic, A Ward… - Science, 2004 - science.org
Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds and
xenobiotics, such as pollutants, environmental compounds, and drug molecules. The …
xenobiotics, such as pollutants, environmental compounds, and drug molecules. The …
[图书][B] The toxicology of fishes
RT Di Giulio, DE Hinton - 2008 - taylorfrancis.com
When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome.
J Dejmek, I Solanský, I Benes, J Lenícek… - Environmental health …, 2000 - ehp.niehs.nih.gov
The relationship between intrauterine growth retardation (IUGR) and exposure to particulate
matter [less than/equal to] 10 microm (PM (10)) and particulate matter [less than and equal …
matter [less than/equal to] 10 microm (PM (10)) and particulate matter [less than and equal …
Quantum mechanically derived AMBER‐compatible heme parameters for various states of the cytochrome P450 catalytic cycle
K Shahrokh, A Orendt, GS Yost… - Journal of …, 2012 - Wiley Online Library
Molecular mechanics (MM) methods are computationally affordable tools for screening
chemical libraries of novel compounds for sites of P450 metabolism. One challenge for MM …
chemical libraries of novel compounds for sites of P450 metabolism. One challenge for MM …
Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
Marked interindividual variability in expression of CYP3A4 influences the disposition of
many endo-and xenobiotics, including the metabolism of steroids, environmental toxins and …
many endo-and xenobiotics, including the metabolism of steroids, environmental toxins and …
[图书][B] Guide to cytochromes P450: structure and function
DFV Lewis - 1996 - taylorfrancis.com
This book covers the relevant aspects of cytochromes P450 for understanding their structure,
function and mechanisms of action, such as physicochemical characterization methods …
function and mechanisms of action, such as physicochemical characterization methods …
Biotransformation in Fishes 1
Chapter 3 in toxicology of fishes addresses the occurrence, regulation, and catalytic
activities of biotransformation systems in fish and concludes with a focus on three model …
activities of biotransformation systems in fish and concludes with a focus on three model …
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin
W Jacobsen, B Kuhn, A Soldner, G Kirchner… - Drug Metabolism and …, 2000 - ASPET
In an in vitro study, we compared the cytochrome P450 (CYP)-dependent metabolism and
drug interactions of the acid and lactone forms of the 3-hydroxy-3-methylglutaryl (HMG)-CoA …
drug interactions of the acid and lactone forms of the 3-hydroxy-3-methylglutaryl (HMG)-CoA …