Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

J Zhang, Y Zhuang, R Sheng, H Tomás… - Materials …, 2024 - pubs.rsc.org
With the increasing and aging of global population, there is a dramatic rise in the demand for
implants or substitutes to rehabilitate bone-related disorders which can considerably …

Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Y Hu, S Li, H Dong, L Weng, L Yuwen… - Advanced …, 2023 - Wiley Online Library
The application of medical implants has greatly improved the survival rate and life quality of
patients. Nevertheless, in recent years, there are increasing cases of implant dysfunction or …

Electrical stimulation of piezoelectric BaTiO3 coated Ti6Al4V scaffolds promotes anti-inflammatory polarization of macrophages and bone repair via MAPK/JNK …

H Wu, H Dong, Z Tang, Y Chen, Y Liu, M Wang, X Wei… - Biomaterials, 2023 - Elsevier
Bone regeneration is a highly synchronized process that requires multiple biochemical,
bioelectrical, mechanical, and other physiological cues. The restoration and delivery of …

Mild photothermal‐stimulation based on injectable and photocurable hydrogels orchestrates immunomodulation and osteogenesis for high‐performance bone …

M Wu, H Liu, Y Zhu, F Chen, Z Chen, L Guo, P Wu, G Li… - Small, 2023 - Wiley Online Library
A photoactivated bone scaffold integrated with minimally invasive implantation and mild
thermal‐stimulation capability shows great promise in the repair and regeneration of …

Bioinspired piezoelectric periosteum to augment bone regeneration via synergistic immunomodulation and osteogenesis

H Liu, Y Shi, Y Zhu, P Wu, Z Deng, Q Dong… - … Applied Materials & …, 2023 - ACS Publications
Ideal periosteum materials are required to participate in a sequence of bone repair-related
physiological events, including the initial immune response, endogenous stem cell …

Dual glucose/ROS-sensitive injectable adhesive self-healing hydrogel with photothermal antibacterial activity and modulation of macrophage polarization for infected …

X Zhou, X Ning, Y Chen, H Chang, D Lu… - ACS Materials …, 2023 - ACS Publications
Antibacterial, anti-inflammatory, and healing-promoting treatment of chronically infected
wounds is not only clinical problems to be solved urgently but also important needs related …

Progress in surface modification of titanium implants by hydrogel coatings

H Chen, R Feng, T Xia, Z Wen, Q Li, X Qiu, B Huang… - Gels, 2023 - mdpi.com
Although titanium and titanium alloys have become the preferred materials for various
medical implants, surface modification technology still needs to be strengthened in order to …

Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation …

M Wu, H Liu, Y Zhu, P Wu, Y Chen, Z Deng… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: The comprehensive management of diabetic bone defects remains a
substantial clinical challenge due to the hostile regenerative microenvironment …

Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal …

M Wu, H Liu, D Li, Y Zhu, P Wu, Z Chen… - Advanced …, 2024 - Wiley Online Library
The treatment of bone defects remains a substantial clinical challenge due to the lack of
spatiotemporal management of the immune microenvironment, revascularization, and …

Thermosensitive nanocomposite hydrogel composed of PVPylated poly (D, L-alanine) and laponite as an injectable and bioactive biomaterial

S Gu, H Wang, Y Wang, X Wang, X Liu, Y Wang… - Chemical Engineering …, 2023 - Elsevier
Abstract Development of regenerative medicine requires multifunctional and bioactive
materials/devices. Herein, we exploit a thermosensitive bioactive nanocomposite hydrogel …