Organogenesis is a complex and interconnected process that is orchestrated by multiple
boundary tissue interactions,,,,,–. However, it remains unclear how individual, neighbouring …

During development, stem cells give rise to specialised cell types in a tightly regulated,
spatiotemporal manner to drive the formation of complex three-dimensional tissues. While …

All pancreatic cell populations arise from the standard gut endoderm layer in developing
embryos, requiring a regulatory gene network to originate and maintain endocrine lineages …

Notch signaling controls proliferation of multipotent pancreatic progenitor cells (MPCs) and
their segregation into bipotent progenitors (BPs) and unipotent pro-acinar cells (PACs) …

About ninety percent of all diabetic conditions account for T2D caused due to abnormal
insulin secretion/action or increased hepatic glucose production. Factors that contribute …

Ectopic tissue is an anatomic abnormality in which tissue develops in an area outside its
normal location. It is primarily caused by abnormalities during the process of embryologic …

The Hippo pathway directs cell differentiation during organogenesis, in part by restricting
proliferation. How Hippo signaling maintains a proliferation-differentiation balance in …

To investigate the role of the vasculature in pancreatic β-cell regeneration, we crossed a
zebrafish β-cell ablation model into the avascular npas4l mutant (ie cloche). Surprisingly, β …

Notch is activated globally in pancreatic progenitors; however, for progenitors to differentiate
into endocrine cells, they must escape Notch activation to express Neurogenin-3. Here, we …

Pancreatic heterotopia is defined as pancreatic tissue outside its normal location in the body
and anatomically separated from the pancreas. In this work we have analyzed the stomach …