DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …

The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …

INTRODUCTION Nucleosomes—the primary, repeating unit of chromatin—package and
protect the genome while also transmitting various regulatory signals through, in part …

The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …

Nuclear proteins bind chromatin to execute and regulate genome-templated processes.
While studies of individual nucleosome interactions have suggested that an acidic patch on …

Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …

Fundamental to our understanding of chromosome duplication is the idea that replication
origins function both as sites where MCM helicases are loaded during the G1 phase and …

Eukaryotic DNA replication is initiated at multiple chromosomal sites known as origins of
replication that are specifically recognized by the origin recognition complex (ORC) …

Class I histone deacetylase complexes play essential roles in many nuclear processes.
Whilst they contain a common catalytic subunit, they have diverse modes of action …

The numerous enzymes and cofactors involved in eukaryotic DNA replication are conserved
from yeast to human, and the budding yeast Saccharomyces cerevisiae (Sc) has been a …