Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise
to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has …

First-order somatosensory neurons transduce and convey information about the external or
internal environment of the body to the central nervous system. They are pseudo unipolar …

The cation channel TRPM3 is activated by heat and the neurosteroid pregnenolone sulfate.
TRPM3 is expressed on sensory neurons innervating the skin, where together with TRPV1 …

This report describes methodological and exploratory investigations of the zymosan-induced
neonatal bladder inflammation (NBI) model of interstitial cystitis/bladder pain syndrome …

This neuroanatomical study in four, adult, Sprague-Dawley female rats quantified the
number of Urothelial (labeled by intravesical DiI dye administration) and Non-Urothelial …

Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder
function, express more than a dozen different ionic membrane mechanisms: ion channels …

Nociceptor cell bodies generate “spontaneous” discharge that can promote ongoing pain in
persistent pain conditions. Little is known about the underlying mechanisms. Recordings …

Bladder-innervating primary sensory neurons mediate reflex-driven bladder function under
normal conditions, and contribute to debilitating bladder pain and/or overactivity in …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition
characterised by urinary urgency, frequency and pelvic pain, that significantly impacts the …

Fast Blue (FB) and Cholera Toxin-B (CTB) are two retrograde tracers extensively used to
label alpha-motoneurons (α-MNs). The overall goals of the present study were to (1) assess …