Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas
J Lukas, J Pospech, C Oppermann, C Hund… - Advances in medical …, 2019 - Elsevier
The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and
secretory proteins. The fraction of protein passing through the ER represents a large …
secretory proteins. The fraction of protein passing through the ER represents a large …
ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs
CRL Webster, SA Center, JM Cullen… - Journal of veterinary …, 2019 - Wiley Online Library
This consensus statement on chronic hepatitis (CH) in dogs is based on the expert opinion
of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical …
of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical …
Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B
The homologous P-type copper-ATPases (Cu-ATPases) ATP7A and ATP7B are the key
regulators of copper homeostasis in mammalian cells. In polarized epithelia, upon copper …
regulators of copper homeostasis in mammalian cells. In polarized epithelia, upon copper …
Polarized trafficking and copper transport activity of ATP7B: A mutational approach to establish genotype–phenotype correlation in Wilson disease
Mutation in ATP7B gene causes Wilson disease (WD) that is characterized by severe
hepatic and neurological symptoms. ATP7B localizes at the trans‐Golgi Network (TGN) …
hepatic and neurological symptoms. ATP7B localizes at the trans‐Golgi Network (TGN) …
ATP7B Binds Ruthenium(II) p-Cymene Half-Sandwich Complexes: Role of Steric Hindrance and Ru–I Coordination in Rescuing the Sequestration
Ruthenium (II/III) complexes are predicted to be efficient alternatives to platinum drug-
resistant cancers but have never been investigated for sequestration and efflux by Cu …
resistant cancers but have never been investigated for sequestration and efflux by Cu …
Retromer retrieves the Wilson disease protein ATP7B from endolysosomes in a copper-dependent manner
The Wilson disease protein, ATP7B maintains copper (herein referring to the Cu+ ion)
homeostasis in the liver. ATP7B traffics from trans-Golgi network to endolysosomes to export …
homeostasis in the liver. ATP7B traffics from trans-Golgi network to endolysosomes to export …
Long-term correction of copper metabolism in Wilson's disease mice with AAV8 vector delivering truncated ATP7B
Y Leng, P Li, L Zhou, L Xiao, Y Liu, Z Zheng… - Human gene …, 2019 - liebertpub.com
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by
mutations in the ATP7B gene encoding a liver active copper transport enzyme. Gene …
mutations in the ATP7B gene encoding a liver active copper transport enzyme. Gene …
Characterization of a fluorescent 1,8-naphthalimide-functionalized PAMAM dendrimer and its Cu(ii) complexes as cytotoxic drugs: EPR and biological studies in …
The activity and interacting ability of a polyamidoamine (PAMAM) dendrimer modified with 4-
N-methylpiperazine-1, 8-naphthalimide units (termed D) and complexed by Cu (ii) ions …
N-methylpiperazine-1, 8-naphthalimide units (termed D) and complexed by Cu (ii) ions …
Wilson disease–causing mutations in the carboxyl terminus of ATP7B regulates its localization and Golgi exit selectively in the unpolarized cells
K Chakraborty, S Das, A Pal, S Maji, B Rai… - Metallomics, 2023 - academic.oup.com
Mutational inactivation of the P-type Cu-ATPase ATP7B interferes with its cellular functions
to varying extent leading to varied cellular phenotypes. Wilson's disease (WD) primarily …
to varying extent leading to varied cellular phenotypes. Wilson's disease (WD) primarily …
Computing the pathogenicity of Wilson's disease ATP7B mutations: implications for disease prevalence
N Tang, TD Sandahl, P Ott, KP Kepp - Journal of Chemical …, 2019 - ACS Publications
Genetic variations in the gene encoding the copper-transport protein ATP7B are the primary
cause of Wilson's disease. Controversially, clinical prevalence seems much smaller than the …
cause of Wilson's disease. Controversially, clinical prevalence seems much smaller than the …