Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome
AP Laurent, RS Kotecha, S Malinge - Leukemia, 2020 - nature.com
Structural and numerical alterations of chromosome 21 are extremely common in
hematological malignancies. While the functional impact of chimeric transcripts from fused …
hematological malignancies. While the functional impact of chimeric transcripts from fused …
Down syndrome and leukemia: An insight into the disease biology and current treatment options
SP Barwe, EA Kolb, A Gopalakrishnapillai - Blood Reviews, 2024 - Elsevier
Children with Down syndrome (DS) have a 10-to 20-fold greater predisposition to develop
acute leukemia compared to the general population, with a skew towards myeloid leukemia …
acute leukemia compared to the general population, with a skew towards myeloid leukemia …
Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and-independent effects of an extra chromosome
As an aneuploidy, trisomy is associated with mammalian embryonic and postnatal
abnormalities. Understanding the underlying mechanisms involved in mutant phenotypes is …
abnormalities. Understanding the underlying mechanisms involved in mutant phenotypes is …
[PDF][PDF] Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes
E Lana-Elola, H Cater… - Disease Models & …, 2021 - journals.biologists.com
ABSTRACT Down syndrome (DS), trisomy 21, results in many complex phenotypes
including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from …
including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from …
[HTML][HTML] The hematopoietic microenvironment of the fetal liver and transient abnormal myelopoiesis associated with Down syndrome: A review
J Miyauchi - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome is a distinct form
of leukemia or preleukemia that mirrors the hematological features of acute …
of leukemia or preleukemia that mirrors the hematological features of acute …
Alteraciones de la serie roja en el síndrome de Down
M Edo Alegre - 2023 - riucv.ucv.es
El síndrome de Down es la cromosomopatía más común en recién nacidos vivos. Se ha
relacionado con alteraciones hematológicas, sobre todo de la serie roja, tales como …
relacionado con alteraciones hematológicas, sobre todo de la serie roja, tales como …
Treatment with β-2 adrenergic receptor agonists: a tool for improving brain developmental alterations in Down syndrome?
M Emili - 2019 - amsdottorato.unibo.it
Down syndrome (DS), a genetic condition (incidence: 800/1000) caused by triplication of
human chromosome 21, is characterized by Intellectual disability (ID) starting from infancy …
human chromosome 21, is characterized by Intellectual disability (ID) starting from infancy …