The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum
Plasmodium falciparum is the causative agent of the most burdensome form of human
malaria, affecting 200–300 million individuals per year worldwide. The recently sequenced …
malaria, affecting 200–300 million individuals per year worldwide. The recently sequenced …
Can an in silico drug-target search method be used to probe potential mechanisms of medicinal plant ingredients?
Covering: 1995–2002 Medicinal plants have been explored therapeutically in traditional
medicines and are a valuable source for drug discovery. Insufficient knowledge about the …
medicines and are a valuable source for drug discovery. Insufficient knowledge about the …
Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites
In this review, we bring together some of the approaches toward understanding the cellular
and molecular biology of Plasmodium species and their interaction with their host red blood …
and molecular biology of Plasmodium species and their interaction with their host red blood …
Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation
X Chen, H Zhou, YB Liu, JF Wang, H Li… - British journal of …, 2006 - Wiley Online Library
Background and purpose: Traditional Chinese Medicine (TCM) is widely practised and is
viewed as an attractive alternative to conventional medicine. Quantitative information about …
viewed as an attractive alternative to conventional medicine. Quantitative information about …
The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony
HM Taylor, L McRobert, M Grainger, A Sicard… - Eukaryotic …, 2010 - Am Soc Microbiol
ABSTRACT A role for the Plasmodium falciparum cyclic GMP (cGMP)-dependent protein
kinase (PfPKG) in gametogenesis in the malaria parasite was elucidated previously. In the …
kinase (PfPKG) in gametogenesis in the malaria parasite was elucidated previously. In the …
A genomic perspective of protein kinases in Plasmodium falciparum
Anamika, N Srinivasan, A Krupa - Proteins: Structure, Function …, 2005 - Wiley Online Library
Protein kinases are central to regulation of cellular signaling in the eukaryotes. Well‐
conserved and lineage‐specific protein kinases have previously been identified from …
conserved and lineage‐specific protein kinases have previously been identified from …
A role for coccidian cGMP-dependent protein kinase in motility and invasion
The coccidian parasite cGMP-dependent protein kinase is the primary target of a novel
coccidiostat, the trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H …
coccidiostat, the trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H …
Using the TOPS-MODE approach to fit multi-target QSAR models for tyrosine kinases inhibitors
Tyrosine kinases constitute an eligible class of target for novel drug discovery. They resulted
often overexpressed and/or deregulated in several cancer diseases. Thus, the development …
often overexpressed and/or deregulated in several cancer diseases. Thus, the development …
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src
BACKGROUND & AIMS:: Cryptosporidium parvum invasion of epithelia requires
polymerization of host cell actin at the attachment site. We analyzed the role of host cell c …
polymerization of host cell actin at the attachment site. We analyzed the role of host cell c …
Plasmodium falciparum: erythrocytic stages die by autophagic-like cell death under drug pressure
PRR Totino, CT Daniel-Ribeiro, S Corte-Real… - Experimental …, 2008 - Elsevier
It has been reported that an apoptotic cell death process can occur with protozoans, but no
consensus on Plasmodium susceptibility to apoptosis was reached till now. Thus, we …
consensus on Plasmodium susceptibility to apoptosis was reached till now. Thus, we …