Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Gastric cancer is one of the deadliest malignant tumors, and half of the patients develop
recurrences or metastasis within 5 years after eradication therapy. Cancer stem cells (CSCs) …

Despite the recent development of precision medicine and targeted therapies, lung cancer
remains the top cause of cancer-related mortality worldwide. The patients diagnosed with …

Abstract Delta Np63 (∆ Np63) is a p63 family member gene with several isoforms, among
which delta Np63 alpha (∆ Np63α) is the predominant isoform expressed in the basal layer …

Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with limited
understanding of its classification and tumor microenvironment. Here, by analyzing single …

Oral cancer is a prevalent global health issue, with significant morbidity and mortality rates.
Despite available preventive measures, it remains one of the most common cancers …

Although numerous putative oncogenes have been associated with the etiology of head and
neck squamous cell carcinoma (HNSCC), the mechanisms by which these oncogenes and …

Exposure to benzo [a] pyrene (B [a] P) has been linked to lung injury and carcinogenesis.
Airway epithelial cells express the B [a] P receptor AHR, so B [a] P is considered to mainly …

The p63 transcription factor is critical for epidermis formation in embryonic development, but
its role in the adult epidermis is poorly understood. In this study, we show that acute genetic …