Advancing from statistical associations of complex traits with genetic markers to
understanding the functional genetic variants that influence traits is often a complex process …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Published genomewide association (GWA) studies typically analyze and report single-
nucleotide polymorphisms (SNPs) and their neighboring genes with the strongest evidence …

Bipolar disorder is a mood disorder characterized by impairing episodes of mania and
depression. Twin studies have established that bipolar disorder is among the most heritable …

Both population-based and family-based designs are commonly used in genetic association
studies to locate genes that underlie complex diseases. The simplest version of the family …

Background The number of genome-wide association studies (GWAS) is growing rapidly
leading to the discovery and replication of many new disease loci. Combining results from …

Autism spectrum disorder (ASD) is a highly heritable disorder of complex and
heterogeneous aetiology. It is primarily characterized by altered cognitive ability including …

A Statistical Approach to Genetic Epidemiology After studying statistics and mathematics at
the University of Munich and obtaining his doctoral degree from the University of Dortmund …

Plant leaves host a specific set of microbial epiphytes. Plant genetic and solar UV-B
radiation effects on the diversity of the phyllosphere were examined by measuring epiphytic …

Many candidate genes have been studied for asthma, but replication has varied. Novel
candidate genes have been identified for various complex diseases using genome-wide …