Chronic rhinosinusitis is characterized by persistent locoregional mucosal inflammation of
the paranasal sinuses and upper airway that has substantial associated health care costs …

Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local
inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS …

Background Integrated care pathways improve the management of patients with chronic
rhinosinusitis with nasal polyps (CRSwNP). The application of integrated care pathways …

The development of biologics targeting various aspects of type 2 inflammation for the
treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) will provide clinicians with …

Background Chronic rhinosinusitis (CRS) is a clinical syndrome primarily characterized by
long-term mucosal inflammation of the nasal cavity and sinuses. The pathogenesis of CRS …

Background The role of periostin, a matricellular protein encoded by the POSTN gene, in
chronic rhinosinusitis with nasal polyposis (CRSwNP) is reviewed. Periostin is considered a …

Chronic rhinosinusitis (CRS) is related to persistent inflammation with a dysfunctional
relationship between environmental agents and the host immune system. Disturbances in …

Introduction Chronic rhinosinusitis (CRS) comprises several heterogenous groups, now
classified based on endotype more often than on phenotype. A number of studies aimed at …

Background Elevated body mass index (BMI) has been associated with an increased
prevalence of chronic rhinosinusitis (CRS). However, the impact of BMI on the risk of …

Background Nasal mucus is proving to be a useful means by which to study the
pathogenesis of chronic rhinosinusitis (CRS). Given the increase in publications examining …