Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) is a potent
mediator involved in the development of HIV-1-associated neurocognitive disorders …

As a popular psychostimulant, methamphetamine (METH) use leads to long-lasting, strong
euphoric effects. While METH abuse is common in the general population, between 10 and …

HIV-1 Tat is a major culprit for HIV/neuroAIDS. One of the consistent hallmarks of
HIV/neuroAIDS is reactive astrocytes or astrocytosis, characterized by increased cytoplasmic …

HIV-1 Tat is an indispensible transactivator for HIV gene transcription and replication. It has
been shown to exit cells as a free protein and enter neighboring cells or interact with surface …

The present study demonstrates HIV-1 Tat-mediated epigenetic downregulation of microglial
miR-124 and its association with microglial activation. Exposure of mouse primary microglia …

HIV infection of astrocytes leads to restricted gene expression and replication but abundant
expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so …

Background Synaptodendritic damage is a pathological hallmark of HIV-associated
neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central …

Alterations in adult neurogenesis have been noted in the brain of HIV-infected individuals
and are likely linked to HIV-associated neurocognitive deficits, including those in learning …

Tat interaction with astrocytes has been shown to be important for Tat neurotoxicity and
HIV/neuroAIDS. We have recently shown that Tat expression leads to increased glial …

Abstract Human Immunodeficiency Virus type-1 (HIV)-associated neurocognitive disorder is
characterized by recruitment of activated/infected leukocytes into the CNS via disrupted …