Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in
any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst …

The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …

Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances …

Biallelic loss-of-function (LOF) mutations of the NCF4 gene, encoding the p40 phox subunit
of the phagocyte NADPH oxidase, have been described in only 1 patient. We report on 24 …

ABSTRACT BCG has been recommended because of its efficacy against disseminated and
meningeal tuberculosis. The BCG vaccine has other mechanisms of action besides …

Background Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated bacterial vaccine
derived from Mycobacterium bovis, which is mostly administered to neonates in regions …

Purpose Chronic granulomatous disease (CGD) is a primary immunodeficiency
characterized by an inability of phagocytes to produce reactive oxygen species, impairing …

Patients with autosomal recessive protein kinase C δ (PKCδ) deficiency suffer from
childhood-onset autoimmunity, including systemic lupus erythematosus. They also suffer …

Background The number of inherited diseases and the spectrum of clinical manifestations of
primary immunodeficiency disorders (PIDs) are ever-expanding. Molecular diagnosis using …

The pathogenesis of tuberculosis (TB) remains poorly understood, as no more than 5–10%
of individuals infected with Mycobacterium tuberculosis go on developing clinical disease …