Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

Sesamum indicum is a major and important oilseed crop that is believed to promote human
health in many countries, especially in China. Sesame seeds contain two types of lignans …

Targeted protein degradation through chemical hijacking of E3 ubiquitin ligases is an
emerging concept in precision medicine. The ubiquitin code is a critical determinant of the …

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide.
Recent studies show that innate immunity-related signaling pathways fuel NAFLD …

Several chemotherapeutics against breast cancer are constrained by their adverse effects
and chemoresistance. The development of novel chemotherapeutics to target metastatic …

Nutrient deprivation is a major trigger of autophagy, a conserved quality control and
recycling process essential for cellular and tissue homeostasis. In a high-content image …

Background Sufentanil combined with parecoxib sodium is a commonly used postoperative
medication for cancer patients. However, the effects of this combination therapy on human …

Mesenchymal glioblastoma (GBM) is highly resistant to radio‐and chemotherapy and
correlates with worse survival outcomes in GBM patients; however, the underlying …

Small interfering RNA (siRNA) has become the cornerstone against undruggable targets
and for managing metastatic breast cancer. However, an effective gene silencing approach …

Simple Summary NEDD4 family members have been investigated to play contributory role in
carcinogenesis. In this review article, we have exclusively focused on the regulation and …