The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases,
with its role in transcription of hundreds of gene well established in the literature. This has …

Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …

Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

Antimalarial agents have routinely been used for the treatment of systemic lupus
erythematosus (SLE) for over 50 years. These agents continue to enjoy success as the initial …

The best known of the naturally occurring antimalarial compounds are quinine, extracted
from cinchona bark, and artemisinin (qinghao), extracted from Artemisia annua in China …

The microaerophilic parasite Giardia lamblia is a causative agent of dysentery affecting
hundreds of millions of people around the globe every year. The symptoms of the disease …

Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Cancer is among the top causes of death, accounting for an estimated 9.6 million deaths in
2018, it appeared that approximately 500,000 people die from cancer in the United States …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …