Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …

Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy.
Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral …

Autophagy is an evolutionarily conserved mechanism of cell adaptation to metabolic and
environmental stress. It mediates the disposal of protein aggregates and dysfunctional …

Vascular calcification (VC) is associated with increased morbidity and mortality, especially
among people with type 2 diabetes mellitus (T2DM). The pathogenesis of vascular …

Abstract Calcium (Ca 2+) plays a central role in regulating many cellular processes and
influences cell survival. Several mechanisms can disrupt Ca 2+ homeostasis to trigger cell …

Ion exchange between intracellular and extracellular spaces is the basic mechanism for
controlling cell metabolism and signal transduction. This process is mediated by ion …

Multiple vaginal delivery (MVD) is an important factor for pelvic floor muscle (PFM) function
decline and pelvic floor dysfunction (PFD). PFD is common in middle-aged and elderly …

Abstract Mibefradil and NNC-55–0396, tetralol derivatives with a proven–ability to block T-
type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell …

Cardiac hypertrophy causes heart failure and is associated with hyperglycemia in patients
with diabetes mellitus. Mibefradil, which acts as a T-type calcium channel blocker, exerts …