Chlamydia spp. are important causes of human disease for which no effective vaccine
exists. These obligate intracellular pathogens replicate in a specialized membrane …

To date, there is rapidly increasing evidence for host–microbe interaction at virtually all
levels of complexity, ranging from direct cell‐to‐cell communication to extensive systemic …

The dynamic nature of gene expression enables cellular programming, homeostasis and
environmental adaptation in living systems. Dissection of causal gene functions in cellular …

Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …

Histone posttranslational modifications control eukaryotic gene expression and regulate
many biological processes including immunity. Pathogens alter host epigenetic control to …

The tight association of the human body with trillions of colonizing microbes that we observe
today is the result of a long evolutionary history. Only very recently have we started to …

The obligate intracellular bacterial pathogen Chlamydia trachomatis (Ctr) has been
associated with cervical and ovarian cancer development. However, establishment of …

Intracellular bacterial pathogens cause a wide range of diseases and significantly contribute
to the morbidity and mortality associated with infectious diseases worldwide (1‐16)(Table 1) …

Mycobacteria are successful pathogens that modulate the host immune response through
unclear mechanisms. Here we show that Rv1988, a secreted mycobacterial protein, is a …

Many bacterial pathogens have evolved the ability to subvert and exploit host functions in
order to enter and replicate in eukaryotic cells. For example, bacteria have developed …