The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its
mechanism still remains with relevant controversies. Some studies defend that early …

Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common
health and economic problem worldwide, and one of the major risk factors for developing …

Immune responses to foreign and self-Ags can be controlled by regulatory T cells (Tregs)
expressing CD4 and IL-2Rα chain (CD25). Defects in Tregs lead to autoimmunity, whereas …

Trichinella spiralis is a helminth that provokes Th2 and anti‐inflammatory type responses in
an infected host. Our previous studies using Dark Agouti (DA) rats indicated that T. spiralis …

ABSTRACT A main feature of acute infection with Trypanosoma cruzi is the presence of
immunological disorders. A previous study demonstrated that acute infection with the …

Helminth infection has a potent systemic immunomodulatory effect on the host immune
response, which also affects the development of autoimmune diseases. We investigated the …

Helminth-derived products, either released into the circulation during the course of the
infection or isolated after in vitro cultivation of the parasite and applied by the injection, are …

Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which
affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the …

The participation of type I IFNs (IFN-I) in NO production and resistance to Trypanosoma cruzi
infection was investigated. Adherent cells obtained from the peritoneal cavity of mice …

Antigen specific T regulatory cells (Treg) are often CD4+ CD25+ FoxP3+ T cells, with a
phenotype similar to natural Treg (nTreg). It is assumed that nTreg cannot develop into an …