Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common
neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that …

INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …

There is an urgent need to develop molecular biomarkers of brain age in order to advance
our understanding of age related neurodegeneration. Recently, we developed a highly …