Modeling Alzheimer's disease with iPSC-derived brain cells
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
[HTML][HTML] A transcription factor atlas of directed differentiation
Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …
processes and cell states. To comprehensively understand TFs and the programs they …
INPP5D regulates inflammasome activation in human microglia
V Chou, RV Pearse, AJ Aylward, N Ashour… - Nature …, 2023 - nature.com
Microglia and neuroinflammation play an important role in the development and progression
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …
A comprehensive library of human transcription factors for cell fate engineering
AHM Ng, P Khoshakhlagh, JE Rojo Arias… - Nature …, 2021 - nature.com
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …
cell types and tissues. To enable systematic exploration of the programming landscape …
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
We have generated a controlled and manipulable resource that captures genetic risk for
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain's major cell types and are responsible for maintaining
neuronal homeostasis via regulating the extracellular environment, providing metabolic …
neuronal homeostasis via regulating the extracellular environment, providing metabolic …
[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use …
Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …
accompanied by a surge of overdose deaths. While opioid dependence has been …
CD49f is a novel marker of functional and reactive human iPSC-derived astrocytes
New methods for investigating human astrocytes are urgently needed, given their critical
role in the central nervous system. Here we show that CD49f is a novel marker for human …
role in the central nervous system. Here we show that CD49f is a novel marker for human …
[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …