In pediatric rhabdomyosarcoma (RMS), elevated Akt signaling is associated with increased
malignancy. Here, we report that expression of a constitutively active, myristoylated form of …

A 70-year-old woman developed severe buttock pain that progressed to a walking
disturbance. Radiographs and computed tomography scans revealed an osteolytic lesion …

Cervical embryonal rhabdomyosarcoma (ERMS) is a rare malignancy. To date, no cases of
ERMS diagnosed by cervical cytology have been reported. In this study, we report a case of …

mTOR activation has been observed in rhabdomyosarcoma (RMS); however, mTOR
complex (mTORC) 1 inhibition has had limited success thus far. mTOR activation alters the …

The diagnosis of primary tumors of bone relies heavily on clinicopathological and
radiological correlation and is often best performed in a multidisciplinary setting. Bone …

The classification of bone sarcomas is still today mainly based on the comparison of
histological, clinical, and radiological criteria. This classification evolves with the …

Alveolar rhabdomyosarcoma (ARMS) is characterized by one of three translocation states: t
(2; 13)(q35; q14) producing PAX3-FOXO1, t (1; 13)(p36; q14) producing PAX7-FOXO1, or …

Background Rhabdomyosarcoma (RMS) is an aggressive malignancy, and 20% of children
present with metastases at diagnosis. Patients presenting with disseminated disease very …

RMS is a malignant tumor of soft tissues affecting primarily children and adolescents.
Around 6% to 23% RMS patients present bone marrow infiltration but leukemia-like …

Local control for the treatment of primary bone tumors is generally delayed following
neoadjuvant chemotherapy. This was born out of the historical need to manufacture custom …