Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …

Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

Chromatin landscapes are disrupted during DNA replication and must be restored faithfully
to maintain genome regulation and cell identity. The histone H3-H4 modification landscape …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

The mucosal epithelium is a common target of damage by chronic bacterial infections and
the accompanying toxins, and most cancers originate from this tissue. We investigated …

Whereas the core nucleosome is thought to serve as a packaging device for the coiling and
contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of …