AMD3100 (plerixafor, Mozobil®) was first identified as an anti-HIV agent specifically active
against the T4-lymphotropic HIV strains, as it selectively blocked the CXCR4 receptor …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

BACKGROUND Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM)
syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function …

CXCR4 WHIM somatic mutations are common Waldenstrom's Macroglobulinemia (WM), and
are associated with clinical resistance to ibrutinib. We engineered WM cells to express the …

Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) is proving successful to treat
several genetic diseases. HSPCs are mobilized, harvested, genetically corrected ex vivo …

WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), a primary
immunodeficiency disorder involving panleukopenia, is caused by autosomal dominant gain …

WHIM syndrome is a rare combined primary immunodeficiency disease named by acronym
for the diagnostic tetrad of warts, hypogammaglobulinemia, infections, and myelokathexis …

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare
immunodeficiency disorder caused by gain-of-function mutations in the G protein–coupled …

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare
primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We …

Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor
endocytosis, and non-canonical signaling via recruitment of β-arrestins. We investigated …