For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

背景本研究旨在比较格列齐特, 利拉鲁肽和二甲双胍对2 型糖尿病合并非酒精性脂肪肝患者的
影响. 方法87 名患者随机接受为期24 周的格列齐特, 利拉鲁肽或二甲双胍治疗 …

The Clinical Practice Guidelines (CPG) propose recommendations for the diagnosis,
treatment and follow-up of non-alcoholic fatty liver disease (NAFLD) patients and are the …

Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common
conditions that regularly co-exist and can act synergistically to drive adverse outcomes. The …

Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …

Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH): NAFLD causes an …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin
resistance and adiposity as its central features. Identifying individuals with metabolic …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …