Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Software tools for microalgae biorefineries: Cultivation, separation, conversion process integration, modeling, and optimization

AA Kasani, A Esmaeili, A Golzary - Algal Research, 2022 - Elsevier
In the operation of biorefineries, performing a quantitative, economic, and environmental
assessment of process equipment design without the use of related software, is time …

Multi-objective process optimisation of beer fermentation via dynamic simulation

AD Rodman, DI Gerogiorgis - Food and Bioproducts Processing, 2016 - Elsevier
Fermentation is an essential step in beer brewing: when yeast is added to hopped wort,
sugars released from the grain during germination are fermented into ethanol and higher …

Multi‐objective optimization applications in chemical engineering

S Sharma, GP Rangaiah - Multi‐Objective Optimization in …, 2013 - Wiley Online Library
In chemical engineering applications, process design and operation need to be optimized
for criteria such as profit, capital cost, conversion, yield and emissions simultaneously …

Multiobjective optimal design for biodiesel sustainable production

A Woinaroschy - Fuel, 2014 - Elsevier
Biodiesel is the most common and most investigated of the alternative diesel fuels due to it
presents many important technical advantages compared to petro-diesel. The major difficulty …

An interactive multi-objective optimization framework for sustainable design of bioprocesses

S Taras, A Woinaroschy - Computers & Chemical Engineering, 2012 - Elsevier
Interactive multi-objective optimization methods have considerable advantages over the
other multi-objective optimization methods and are well suited for biochemical engineering …

A paradigm-based evolution of chemical engineering

A Woinaroschy - Chinese Journal of Chemical Engineering, 2016 - Elsevier
A short presentation of chemical engineering evolution, as guided by its paradigms, is
exposed. The first paradigm–unit operations–has emerged as a necessity of systematization …

Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress

C Ding, O Yang, M Ierapetritou - … Manufacturing: Progress, Trends and …, 2024 - Springer
The capabilities of digital twins (DT) and the successes they have demonstrated in various
industries have attracted significant attention from the biopharmaceutical manufacturing …

Process simulation of integrated xanthan gum and sorbitol bioproduction: economic and sensitivity analysis with Taguchi approach

DD Saydam, A Koulouris, AC Dalgıç - Process Integration and Optimization …, 2020 - Springer
The main objective of this study is to evaluate the economics of xanthan gum manufacturing
in an integrated system with sorbitol productions from sugar beet molasses using SuperPro …

[PDF][PDF] The paradigms of chemical engineering

A Woinaroschy - AGIR Bulletin, 2015 - agir.ro
It is presented the chemical engineering development, as guided by its four main paradigms:
unit operations, transport phenomena, product engineering and sustainable chemical …