Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …

Abstract Changes in the micro-environment of fibrous connective tissue can lead to
alterations in the phenotypes of tissue-resident cells, yet the underlying mechanisms are …

Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

Cranial sutures are major growth centers for the calvarial vault, and their premature fusion
leads to a pathologic condition called craniosynostosis. This study investigates whether …

Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …

Bone is a complex endocrine organ that facilitates structural support, protection to vital
organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow …

Wnt is a major signaling pathway involved in multifaceted roles of various biological
processes. Bones are dynamic tissues which are able to remodel and maintain the tissue …

Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at
lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and …