The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …

In the eukaryotic cell, capping of mRNA 5′ ends is an essential structural modification that
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the
synthesis of their RNA (s). In the case of positive-stranded RNA viruses belonging to the …

Currently, the understanding of the relationships between function, amino acid sequence,
and protein structure continues to represent one of the major challenges of the modern …

RNA ligases are present across all forms of life. While enzymatic RNA ligation between 5′-
PO4 and 3′-OH termini is prevalent in viruses, fungi, and plants, such RNA ligases are yet …

Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus
that it emerged before DNA and proteins, which eventually assumed these roles and …

T4 RNA ligases are commonly used to attach adapters to RNAs, but large differences in
ligation efficiency make detection and quantitation problematic. We developed a ligation …

Jumbo phages have attracted much attention by virtue of their extraordinary genome size
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …

Coronaviruses and arteriviruses are distantly related human and animal pathogens that
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …