HMGA2 as a critical regulator in cancer development
The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …
HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
The role of miRNAs in regulating gene expression networks
AM Gurtan, PA Sharp - Journal of molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …
species, expressed across cell types, and active against a large proportion of the …
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign
mesenchymal tumors and lung cancers. Knockdown of Dicer in HeLa cells revealed that the …
mesenchymal tumors and lung cancers. Knockdown of Dicer in HeLa cells revealed that the …
Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1
Abstract Using RNA sequencing (RNA-Seq), we compared the expression patterns of
circular RNAs in proliferating (early-passage) and senescent (late-passage) human diploid …
circular RNAs in proliferating (early-passage) and senescent (late-passage) human diploid …
[HTML][HTML] Oncological role of HMGA2
S Zhang, Q Mo, X Wang - International journal of …, 2019 - spandidos-publications.com
The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription
factor that modulates the transcription of several genes by binding to AT‑rich sequences in …
factor that modulates the transcription of several genes by binding to AT‑rich sequences in …
HMG chromosomal proteins in development and disease
R Hock, T Furusawa, T Ueda, M Bustin - Trends in cell biology, 2007 - cell.com
The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous
nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the …
nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the …
Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to let-7 MicroRNA Family
K Motoyama, H Inoue, Y Nakamura, H Uetake… - Clinical cancer …, 2008 - AACR
Purpose: The high mobility group A2 (HMGA2) nonhistone chromosomal protein can
modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during …
modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during …
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2
SM Park, S Shell, AR Radjabi, R Schickel, C Feig… - Cell cycle, 2007 - Taylor & Francis
The microRNA let-7 regulates late embryonic development by suppressing expression of a
number of genes such as c-myc and RAS as well as the embryonic gene high mobility …
number of genes such as c-myc and RAS as well as the embryonic gene high mobility …