We propose that excessive fructose intake (> 50 g/d) may be one of the underlying etiologies
of metabolic syndrome and type 2 diabetes. The primary sources of fructose are sugar …

The metabolic syndrome is an important public health concern that predisposes individuals
to the development of cardiovascular disease and/or Type 2 diabetes. The fructose-fed rat is …

The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

Background Insulin resistance is a key component of the insulin resistance syndrome and is
a crucially important metabolic abnormality in Type 2 diabetes. Insulin‐resistant individuals …

Background Dahl salt-sensitive (Dahl S) rats exhibit many phenotypic traits associated with
salt-sensitive hypertension in man. Specifically, they are salt-sensitive, insulin-resistant and …

It is now well established that obesity is an independent risk factor for the development of
coronary artery atherosclerosis. The maintenance of vascular homeostasis is critically …

We are currently in the midst of an epidemic of metabolic disorders, which may, in part, be
explained by excess fructose intake. This theory is supported by epidemiological …

Vascular biology assumes a pivotal role in the initiation and perpetuation of hypertension
and target organ damage sequelae. Endothelial activation, oxidative stress, and vascular …

Background: Little is known about the effects of dietary fiber intake on long-term mortality.
Objective: We aimed to study recent and long-term dietary fiber intake in relation to coronary …

Endothelin-1 (ET-1) is a vasoconstrictor secreted by endothelial cells, which acts as the
natural counterpart of the vasodilator nitric oxide (NO). ET-1 contributes to vascular tone and …