Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and
oncological diseases through clinical genetics and gene disruption in mice. New selective …

Innate immunity plays a crucial role in the response to sterile inflammation such as liver
ischemia/reperfusion (I/R) injury. The initiation of liver I/R injury results in the release of …

NETosis, the process wherein neutrophils release highly decondensed chromatin called
neutrophil extracellular traps (NETs), has gained much attention as an alternative means of …

Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally
encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in …

Peptidylarginine deiminases are a family of enzymes that mediate post-translational
modifications of protein arginine residues by deimination or demethylimination to produce …

Excessive or aberrant generation of neutrophil extracellular traps (NETs) has recently
become implicated in the underlying aetiology of a number of human pathologies including …

NETosis is a type of regulated cell death dependent on the formation of neutrophil
extracellular traps (NET), where net-like structures of decondensed chromatin and proteases …

Neutrophils have long been known as innate immune cells that phagocytose and kill
pathogens and mount inflammatory responses protecting the host from infection. In the past …