Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Evidence has emerged in the last two decades that at the molecular level most chronic
diseases, including cancer, are caused by a dysregulated inflammatory response. The …

Multiple myeloma (MM) is typically exemplified by a desynchronized cytokine system with
increased levels of inflammatory cytokines. We focused on the contrast between …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck
cancers, and distant metastasis is the major reason for treatment failure. We have previously …

Discovery and development of novel anti-cancer drugs are expensive and time consuming.
Systems biology approaches have revealed that a drug being developed for a non-cancer …

Multiple myeloma (MM) is an essentially incurable malignancy associated with profound
immune dysregulation. Despite the advent of novel therapies and improvements in survival …

There is much interest in the potential use of Cox-2 selective inhibitors in combination with
other cancer therapeutics. Malignancies of hematopoietic and non-hematopoietic origin …

Abstract The cyclooxygenase-2 (COX-2) enzyme catalyses the first stage of biosynthesis of
prostanoids, proteins that are implicated in various physiological and pathological …

Multiple myeloma (MM) is an incurable disease, characterized by malignant plasma cells in
the bone marrow. MM growth is largely dependent on the tumor microenvironment (TME) …