mRNA sequences to control co-translational folding of proteins

AK Sharma, EP O'brien - US Patent 10,724,040, 2020 - Google Patents
This invention relates to optimized heterologous production of properly folded and functional
proteins. The present invention provides systems and methods involving determination of …

ROR1 targeting chimeric antigen receptor

P Spencer, Q Vong, B Sather, B Ryu, M Lajoie… - US Patent …, 2024 - Google Patents
2024-10-02 Assigned to LYELL IMMUNOPHARMA, INC. reassignment LYELL
IMMUNOPHARMA, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Vector containing centromere DNA sequence and use thereof

T Nishi, T Nishiyama, T Watanabe, Y Okubo - US Patent 11,214,809, 2022 - Google Patents
(57) ABSTRACT A vector is provided that includes a nucleotide sequence selected from any
one of (a) to (d). The selection of (a) to (d) includes:(a) the nucleotide sequence set forth in …

Anti-microbial and UV-protective extracts and methods of making and using thereof

RC Rengifo, JL MURILLO - US Patent 11,692,192, 2023 - Google Patents
Described herein are anti-microbial and UV-protective biological devices and extracts
produced therefrom. The biological devices include microbial cells transformed with a DNA …

Codon optimization method based on immune algorithm

L Fan, Y Sun, D Wu, L Zhang, Z Liu - US Patent App. 16/633,910, 2021 - Google Patents
Codon degeneracy refers to the phenomenon that an amino acid can be encoded by
multiple different codons during protein translation. The different codons encoding the same …

Method of producing a recombinant protein

RA Emmins, GB Finka, M Hoare, AP Lewis… - US Patent …, 2021 - Google Patents
The present invention relates to a recombinant signal sequence derived from E. coli. The
invention also relates to a fusion protein comprising the signal sequence, a recombinant …

Over-expression of AZF1 improves the rate of anaerobic xylose fermentation in engineered yeast strains

AP Gasch, K Myers - US Patent 11,591,376, 2023 - Google Patents
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL
TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL …

Method of producing a recombinant protein

RA EMMINS, GB Finka, M Hoare, AP Lewis… - 2019 - Google Patents
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-
oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo …

Compositions for adjustable ribosome translation speed and methods of use

KT Hughes, F Chevance - US Patent 11,293,028, 2022 - Google Patents
Goodman, DB, et al.,“Causes and effects of N-terminal codon bias in bacterial genes,”
Science 342: 475-478 (2013). Nei, M.“Selectionism and neutralism in molecular evolution,” …

Method and system for designing polynucleotide sequences and polynucleotide sequences obtained thereby

T Tuller, H Zur - US Patent 11,610,650, 2023 - Google Patents
US11610650B2 - Method and system for designing polynucleotide sequences and
polynucleotide sequences obtained thereby - Google Patents US11610650B2 - Method …