Multifunctional Cytochrome c: Learning New Tricks from an Old Dog

D Alvarez-Paggi, L Hannibal, MA Castro… - Chemical …, 2017 - ACS Publications
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

M Hüttemann, P Pecina, M Rainbolt, TH Sanderson… - Mitochondrion, 2011 - Elsevier
Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

Metabolism and function of mitochondrial cardiolipin

M Ren, CKL Phoon, M Schlame - Progress in lipid research, 2014 - Elsevier
Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

VE Kagan, HA Bayır, NA Belikova, O Kapralov… - Free Radical Biology …, 2009 - Elsevier
Recently, phospholipid peroxidation products gained a reputation as key regulatory
molecules and participants in oxidative signaling pathways. During apoptosis, a …

Biodegradation of single-walled carbon nanotubes through enzymatic catalysis

BL Allen, PD Kichambare, P Gou, II Vlasova… - Nano …, 2008 - ACS Publications
We show here the biodegradation of single-walled carbon nanotubes through natural,
enzymatic catalysis. By incubating nanotubes with a natural horseradish peroxidase (HRP) …

Peroxidase activity of human hemoproteins: keeping the fire under control

II Vlasova - Molecules, 2018 - mdpi.com
The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly
reactive intermediates, which then oxidize simple substances called peroxidase substrates …

Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease

M Hüttemann, I Lee, A Pecinova, P Pecina… - Journal of bioenergetics …, 2008 - Springer
Abstract Thirty years after Peter Mitchell was awarded the Nobel Prize for the chemiosmotic
hypothesis, which links the mitochondrial membrane potential generated by the proton …

[HTML][HTML] Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

ZT Schug, E Gottlieb - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2009 - Elsevier
Cardiolipin (CL) is a unique anionic phospholipid specific to the mitochondria. CL influences
the activity of electron transport chain enzyme complexes as well as members of the Bcl-2 …

Therapies targeting lipid peroxidation in traumatic brain injury

TS Anthonymuthu, EM Kenny, H Bayır - Brain research, 2016 - Elsevier
Lipid peroxidation can be broadly defined as the process of inserting a hydroperoxy group
into a lipid. Polyunsaturated fatty acids present in the phospholipids are often the targets for …

Cardiolipin interactions with proteins

J Planas-Iglesias, H Dwarakanath, D Mohammadyani… - Biophysical journal, 2015 - cell.com
Cardiolipins (CL) represent unique phospholipids of bacteria and eukaryotic mitochondria
with four acyl chains and two phosphate groups that have been implicated in numerous …