Interventional pharmacoeconomics for immune checkpoint inhibitors through alternative dosing strategies

A Wesevich, DA Goldstein, K Paydary, CJ Peer… - British journal of …, 2023 - nature.com
Immune checkpoint inhibitors (ICIs) are approved for the treatment of a variety of cancer
types. The doses of these drugs, though approved by the Food and Drug Administration …

Alternative dosing strategies for immune checkpoint inhibitors to improve cost-effectiveness: a special focus on nivolumab and pembrolizumab

R Malmberg, M Zietse, DW Dumoulin… - The Lancet …, 2022 - thelancet.com
Immune checkpoint inhibitors have revolutionised cancer treatment by offering durable
responses to many patients with solid and haematological cancers. The high prices and …

Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer

JE Yu, IJ Yeo, SB Han, J Yun, B Kim, YJ Yong… - … & Molecular Medicine, 2024 - nature.com
Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …

Immunotherapy of thymic epithelial tumors: molecular understandings and clinical perspectives

YQ Ao, J Gao, S Wang, JH Jiang, J Deng, HK Wang… - Molecular Cancer, 2023 - Springer
Immunotherapy has emerged to play a rapidly expanding role in the treatment of cancers.
Currently, many clinical trials of therapeutic agents are on ongoing with majority of immune …

Dosing regimens of immune checkpoint inhibitors: attempts at lower dose, less frequency, shorter course

M Jiang, Y Hu, G Lin, C Chen - Frontiers in Oncology, 2022 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are a revolutionary breakthrough in the field of cancer by
modulating patient's own immune system to exert anti-tumor effects. The clinical application …

REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment

E Ghorani, M Quartagno, F Blackhall, DC Gilbert… - The Lancet …, 2023 - thelancet.com
Increasing evidence suggests that some immunotherapy dosing regimens for patients with
advanced cancer could result in overtreatment. Given the high costs of these agents, and …

Pharmacokinetic simulation analysis of less frequent nivolumab and pembrolizumab dosing: pharmacoeconomic rationale for dose deescalation

CJ Peer, BL Heiss, DA Goldstein… - The Journal of …, 2022 - Wiley Online Library
Nivolumab and pembrolizumab, anti–programmed cell death protein 1 monoclonal
antibodies, have revolutionized oncology but are expensive. Using an interventional …

What is the optimal duration, dose and frequency for anti-PD1 therapy of non-small cell lung cancer?

CY Kuah, R Monfries, M Quartagno… - Therapeutic …, 2023 - journals.sagepub.com
Over the past decade, immune checkpoint inhibitors (ICIs) have transformed the
management of multiple malignancies including lung cancer. However, the optimal use of …

Immune-therapy-related toxicity events and dramatic remission after a single dose of pembrolizumab treatment in metastatic thymoma: a case report

L Shen, H Chen, Q Wei - Frontiers in Immunology, 2021 - frontiersin.org
Immune checkpoint inhibitor therapy has become a promising option for the treatment of late-
stage thymic epithelial tumors. In this manuscript, we presented a patient with metastatic …

Tuning Surface Plasmon Resonance Responses through Size and Crosslinking Control of Multivalent Protein Binding-Capable Nanoscale Hydrogels

JY Teoh, S Jeon, B Yim, HM Yang… - ACS Biomaterials …, 2022 - ACS Publications
Surface plasmon resonance (SPR) phenomena have been widely studied to detect
biomolecules because of their high sensitivity and ability to determine biomolecular …