A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

To reveal if coagulopathies relate to the course of COVID-19, we examined 255 patients with
moderate and severe COVID-19, receiving anticoagulants and immunosuppressive drugs …

While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …

Background Blood clot contraction, volume shrinkage of the clot, is driven by platelet
contraction and accompanied by compaction of the erythrocytes and their gradual shape …

The severity, course, and outcomes of thrombosis are determined mainly by the size and
location of the thrombus, but studying thrombus structure and composition has been an …

Blood clots and thrombi undergo platelet-driven contraction/retraction followed by structural
rearrangements. We have established quantitative relationships between the composition of …

Background Piezo1 is a mechanosensitive cationic channel that boosts intracellular [Ca 2+]
i. Compression of red blood cells (RBCs) during platelet-driven contraction of blood clots …

Autoimmune diseases, including systemic lupus erythematosus (SLE), have a high risk of
thrombotic and hemorrhagic complications associated with altered platelet functionality. We …

Rheumatoid arthritis (RA) is an autoimmune disease associated with thrombotic
complications. To elucidate pathogenic mechanisms, hemostatic disorders in RA were …

Mutations in the MYH9 gene result in macrothrombocytopenia often associated with
hemorrhages. Here, we studied the function and structure of platelets in three family …