Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful
immunotherapeutic tools for combating hematological diseases confronted with pressing …

Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

CAR-T-cell therapy against MM currently shows promising results, but usually with serious
toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma …

Simple Summary HER2-positive breast cancer (BC), which accounts for~ 20% of BC, is one
of the more aggressive and has the worst overall survival rate among them. These patients …

Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …

The development of chimeric antigen receptor T (CAR-T) cell therapy, a specific type of
immunotherapy, in recent decades was a fantastic breakthrough for the treatment of …

T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the
field of cellular therapy for cancer. Despite its success, this strategy has some recognised …