Organisms from all domains of life depend on filaments of the protein actin to provide
structure and to support internal movements. Many eukaryotic cells use forces produced by …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

The molecular mechanisms underlying the response to exercise and inactivity are not fully
understood. We propose an innovative approach to profile the skeletal muscle transcriptome …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

Hair cells of the inner ear are essential for hearing and balance. As a consequence,
pathogenic variants in genes specifically expressed in hair cells often cause hereditary …

Stress fibers (SFs) are often the most prominent cytoskeletal structures in cells growing in
tissue culture. Composed of actin filaments, myosin II, and many other proteins, SFs are …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …