Growth hormone in fertility and infertility: Mechanisms of action and clinical applications

CW Chang, YW Sung, YW Hsueh, YY Chen… - Frontiers in …, 2022 - frontiersin.org
Secreted by the anterior pituitary gland, growth hormone (GH) is a peptide that plays a
critical role in regulating cell growth, development, and metabolism in multiple targeted …

Targeting CREB in cancer therapy: a key candidate or one of many? An update

L Sapio, A Salzillo, A Ragone, M Illiano, A Spina… - Cancers, 2020 - mdpi.com
Simple Summary Only 5% of all drug-related targets currently move from preclinical to
clinical in cancer, and just some of them achieve patient's bedside. Among others, intratumor …

Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

Y Gong, S Luo, P Fan, H Zhu, Y Li, W Huang - Reproductive Biology and …, 2020 - Springer
Background It is reported that growth hormone (GH) can alleviate oxidative stress (OS)
induced apoptosis in some types of cells by activating the PI3K/Akt signaling pathway. This …

Circulating metabolite homeostasis achieved through mass action

X Li, S Hui, ET Mirek, WO Jonsson, TG Anthony… - Nature …, 2022 - nature.com
Homeostasis maintains serum metabolites within physiological ranges. For glucose, this
requires insulin, which suppresses glucose production while accelerating its consumption …

Dietary niacin requirement of Pacific white shrimp (Litopenaeus vannamei)

M Hasanthi, KJ Lee - Aquaculture, 2023 - Elsevier
A study was conducted to evaluate the dietary requirement of niacin (vitamin B 3) and its
effects on the growth, feed utilization, immunity, and disease resistance of Pacific white …

The molecular mechanism of sex hormones on Sertoli cell development and proliferation

W Shah, R Khan, B Shah, A Khan, S Dil… - Frontiers in …, 2021 - frontiersin.org
Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Preweaning period is a critical window for rumen microbial regulation of average daily gain in Holstein heifer calves

S Xu, C Jiao, Q Diao, Y Tu - Journal of Animal Science and Biotechnology, 2023 - Springer
Background Rumen bacterial groups can affect growth performance, such as average daily
gain (ADG), feed intake, and efficiency. The study aimed to investigate the inter-relationship …

Decreased USP2a expression inhibits trophoblast invasion and associates with recurrent miscarriage

J Wang, J Ding, S Zhang, X Chen, S Yan… - Frontiers in …, 2021 - frontiersin.org
An appropriate development of the placenta consisting of trophoblast cell migration,
invasion, proliferation, and apoptosis, is essential to establishing and maintaining a …

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails

GK Reda, SF Ndunguru, B Csernus, R Knop… - Scientific Reports, 2024 - nature.com
Limited resources affect an organism's physiology through the conserved metabolic
pathway, the mechanistic target of rapamycin (mTOR). Males and females often react …

Relative Energy Deficiency in sport (REDs): endocrine manifestations, pathophysiology and treatments

AM Angelidi, K Stefanakis, SH Chou… - Endocrine …, 2024 - academic.oup.com
Research on lean, energy-deficient athletic and military cohorts has broadened the concept
of the Female Athlete Triad into the Relative Energy Deficiency in Sport (REDs) syndrome …