Obesity, POMC, and POMC-processing enzymes: surprising results from animal models
I Lindberg, LD Fricker - Endocrinology, 2021 - academic.oup.com
Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides
and peptide hormones that perform multiple functions, including regulation of body weight …
and peptide hormones that perform multiple functions, including regulation of body weight …
Disentangling genetic risks for metabolic syndrome
A quarter of the world's population is estimated to meet the criteria for metabolic syndrome
(MetS), a cluster of cardiometabolic risk factors that promote development of coronary artery …
(MetS), a cluster of cardiometabolic risk factors that promote development of coronary artery …
Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity
DJ Drucker - Diabetes Care, 2024 - Am Diabetes Assoc
The development of glucagon-like peptide 1 receptor agonists (GLP-1RA) for type 2
diabetes and obesity was followed by data establishing the cardiorenal benefits of GLP-1RA …
diabetes and obesity was followed by data establishing the cardiorenal benefits of GLP-1RA …
Association of rare protein-truncating DNA variants in APOB or PCSK9 with low-density lipoprotein cholesterol level and risk of coronary heart disease
Importance Protein-truncating variants (PTVs) in apolipoprotein B (APOB) and proprotein
convertase subtilisin/kexin type 9 (PCSK9) are associated with significantly lower low …
convertase subtilisin/kexin type 9 (PCSK9) are associated with significantly lower low …
[PDF][PDF] Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes
JU Melchiorsen, KV Sørensen… - The Journal of …, 2023 - academic.oup.com
Context Lost glucagon-like peptide 1 receptor (GLP-1R) function affects human physiology.
Objective This work aimed to identify coding nonsynonymous GLP1R variants in Danish …
Objective This work aimed to identify coding nonsynonymous GLP1R variants in Danish …
Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans
Abstract Growth differentiation factor-15 (GDF15) is a stress response cytokine that is
elevated in several cardiometabolic diseases and has attracted interest as a potential …
elevated in several cardiometabolic diseases and has attracted interest as a potential …