Oncogenic effects of HIV-1 proteins, mechanisms behind

M Isaguliants, E Bayurova, D Avdoshina… - Cancers, 2021 - mdpi.com
Simple Summary People living with human immunodeficiency virus type 1 (HIV-1)(PLWH)
are at increased risk of developing cancer despite successful antiretroviral therapy (ART) …

HIV-associated Burkitt lymphoma

SA Atallah-Yunes, DJ Murphy, A Noy - The Lancet Haematology, 2020 - thelancet.com
Burkitt lymphoma is a rare and aggressive non-Hodgkin lymphoma with three classifications:
endemic, sporadic, and immunodeficiency-related. High-intensity chemotherapeutic …

[HTML][HTML] Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: a mechanism involving calcium overload/XO/ROS/mPTP pathway

P Zhu, S Hu, Q Jin, D Li, F Tian, S Toan, Y Li, H Zhou… - Redox biology, 2018 - Elsevier
Abstract Receptor-interacting protein 3 (Ripk3)-mediated necroptosis contributes to cardiac
ischaemia-reperfusion (IR) injury through poorly defined mechanisms. Our results …

Oncogenic properties of the EBV ZEBRA protein

D Germini, FB Sall, A Shmakova, J Wiels… - Cancers, 2020 - mdpi.com
Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary
infection, it can persist in the host throughout their lifetime in a latent form, from which it can …

[HTML][HTML] HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress

A Thangaraj, ET Chivero, A Tripathi, S Singh, F Niu… - Redox Biology, 2021 - Elsevier
The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has
not only resulted in a dramatic decrease in the peripheral viral load but has also led to …

Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress

IL Shytaj, FA Procopio, M Tarek… - EMBO molecular …, 2021 - embopress.org
HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir
responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a …

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical …

H Mataramvura, MJ Bunders, K Duri - Frontiers in immunology, 2023 - frontiersin.org
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis
(Option B+) has dramatically improved the health of HIV-infected women and their children …

Oncogenic viral infection and amino acid metabolism in cancer progression: Molecular insights and clinical implications

N Liu, F Shi, L Yang, W Liao, Y Cao - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Viruses lack essential living system, so they must hijack host cell metabolism for its survival
and reproduction. Interestingly, the metabolic reprogramming induced by oncovirus is critical …

HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis

S Sil, G Hu, K Liao, F Niu, S Callen, P Periyasamy… - PLoS …, 2020 - journals.plos.org
Increased life expectancy of patients diagnosed with HIV in the current era of antiretroviral
therapy is unfortunately accompanied with the prevalence of HIV-associated neurocognitive …

HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation

M Doke, V Jeganathan, JP McLaughlin… - Epigenetics, 2021 - Taylor & Francis
Human immunodeficiency virus (HIV) infection and the psychostimulant drug cocaine are
known to induce epigenetic changes in DNA methylation that are linked with the severity of …