Influence of ionic inorganic solutes on self-assembly and polymerization processes related to early forms of life: Implications for a prebiotic aqueous medium
PA Monnard, CL Apel, A Kanavarioti, DW Deamer - Astrobiology, 2002 - liebertpub.com
A commonly accepted view is that life began in a marine environment, which would imply
the presence of inorganic ions such as Na+, Cl-, Mg2+, Ca2+, and Fe2+. We have …
the presence of inorganic ions such as Na+, Cl-, Mg2+, Ca2+, and Fe2+. We have …
Eutectic phases in ice facilitate nonenzymatic nucleic acid synthesis
Polymeric compounds similar to oligonucleotides are relevant to the origin of life and
particularly to the concept of an RNA world. Although short oligomers of RNA can be …
particularly to the concept of an RNA world. Although short oligomers of RNA can be …
Surface-catalyzed hydrolysis by pyrogenic carbonaceous matter and model polymers: An experimental and computational study on functional group and pore …
We employed a polymer network to understand what properties of pyrogenic carbonaceous
matter (PCM; eg., activated carbon) confer its reactivity, which we hereinafter referred to as …
matter (PCM; eg., activated carbon) confer its reactivity, which we hereinafter referred to as …
Templating efficiency of naked DNA
E Kervio, A Hochgesand… - Proceedings of the …, 2010 - National Acad Sciences
Template-directed synthesis of complementary strands is pivotal for life. Nature employs
polymerases for this reaction, leaving the ability of DNA itself to direct the incorporation of …
polymerases for this reaction, leaving the ability of DNA itself to direct the incorporation of …
Accelerating chemical replication steps of RNA involving activated ribonucleotides and downstream-binding elements
SR Vogel, C Deck, C Richert - Chemical Communications, 2005 - pubs.rsc.org
Accelerating chemical replication steps of RNA involving activated ribonucleotides and
downstream-binding elements - Chemical Communications (RSC Publishing) DOI:10.1039/B510775J …
downstream-binding elements - Chemical Communications (RSC Publishing) DOI:10.1039/B510775J …
Dimerization in highly concentrated solutions of phosphoimidazolide activated mononucleotides
A Kanavarioti - Origins of Life and Evolution of the Biosphere, 1997 - Springer
Phosphoimidazolide activated ribomononucleotides (* pN) are useful substrates for the non-
enzymatic synthesis of polynucleotides. However, dilute neutral aqueous solutions of* pN …
enzymatic synthesis of polynucleotides. However, dilute neutral aqueous solutions of* pN …
Relative reactivity of ribosyl 2′-OH vs. 3′-OH in concentrated aqueous solutions of phosphoimidazolide activated nucleotides
A Kanavarioti, LF Lee, S Gangopadhyay - Origins of life and evolution of …, 1999 - Springer
Phosphoimidazolide activated ribomononucleotides (* pN, see structure) are useful
substrates for the non-enzymatic synthesis of oligonucleotides. In the presence of metal …
substrates for the non-enzymatic synthesis of oligonucleotides. In the presence of metal …
A steroid cap adjusts the selectivity and accelerates the rates of nonenzymatic single nucleotide extensions of an oligonucleotide
JA Rojas Stütz, C Richert - Journal of the American Chemical …, 2001 - ACS Publications
The template-directed extension of polynucleotide chains by individual residues underlies
DNA replication. In nature, this reaction is catalyzed by DNA polymerases. 1 These are …
DNA replication. In nature, this reaction is catalyzed by DNA polymerases. 1 These are …
Use of phosphoimidazolide-activated guanosine to investigate the nucleophilicity of spermine and spermidine
A Kanavarioti, EE Baird, PJ Smith - The Journal of organic …, 1995 - ACS Publications
Materials and Methods Materials. 2-MeImpG (96% pure) was synthesized by a
modification14 of a published procedure. 15 1-Hexane-sulfonic acid (1-HSA), spectroscopic …
modification14 of a published procedure. 15 1-Hexane-sulfonic acid (1-HSA), spectroscopic …
Preference for internucleotide linkages as a function of the number of constituents in a mixture
A Kanavarioti - Journal of molecular evolution, 1998 - Springer
Phosphoimidazolide-activated ribomononucleotides (* pN; see Scheme I) are useful
substrates for the nonenzymatic synthesis of oligonucleotides. In the presence of metal ions …
substrates for the nonenzymatic synthesis of oligonucleotides. In the presence of metal ions …