Quorum quenching: role in nature and applied developments

C Grandclément, M Tannières, S Moréra… - FEMS microbiology …, 2016 - academic.oup.com
Quorum sensing (QS) refers to the capacity of bacteria to monitor their population density
and regulate gene expression accordingly: the QS-regulated processes deal with …

Homocysteine modification in protein structure/function and human disease

H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis

RA Kamber, Y Nishiga, B Morton, AM Banuelos… - Nature, 2021 - nature.com
Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …

Expanding the enzyme universe: accessing non‐natural reactions by mechanism‐guided directed evolution

H Renata, ZJ Wang, FH Arnold - … Chemie International Edition, 2015 - Wiley Online Library
High selectivity and exquisite control over the outcome of reactions entice chemists to use
biocatalysts in organic synthesis. However, many useful reactions are not accessible …

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Y Huang, Z Wu, M Riwanto, S Gao… - The Journal of …, 2013 - Am Soc Clin Investig
Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein–
associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress …

Shining a light on enzyme promiscuity

SD Copley - Current opinion in structural biology, 2017 - Elsevier
Highlights•Screening efforts have revealed enzymes with over 100 promiscuous
activities.•High-throughput screening for promiscuous activities can be accomplished in …

The structure and function of paraoxonase-1 and its comparison to paraoxonase-2 and-3

A Taler-Verčič, M Goličnik, A Bavec - Molecules, 2020 - mdpi.com
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases
(PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and …

Advances and applications of chemical protective clothing system

MAR Bhuiyan, L Wang, A Shaid… - Journal of Industrial …, 2019 - journals.sagepub.com
Protection is obligatory for the safety of people in certain occupations where they might be
exposed to hazardous chemicals. This review provides an overview of chemical protective …

Enzyme promiscuity: engine of evolutionary innovation

C Pandya, JD Farelli, D Dunaway-Mariano… - Journal of Biological …, 2014 - ASBMB
Catalytic promiscuity and substrate ambiguity are keys to evolvability, which in turn is pivotal
to the successful acquisition of novel biological functions. Action on multiple substrates …

Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors

IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium‐
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …