Quorum quenching: role in nature and applied developments
C Grandclément, M Tannières, S Moréra… - FEMS microbiology …, 2016 - academic.oup.com
Quorum sensing (QS) refers to the capacity of bacteria to monitor their population density
and regulate gene expression accordingly: the QS-regulated processes deal with …
and regulate gene expression accordingly: the QS-regulated processes deal with …
Homocysteine modification in protein structure/function and human disease
H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis
RA Kamber, Y Nishiga, B Morton, AM Banuelos… - Nature, 2021 - nature.com
Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …
Expanding the enzyme universe: accessing non‐natural reactions by mechanism‐guided directed evolution
High selectivity and exquisite control over the outcome of reactions entice chemists to use
biocatalysts in organic synthesis. However, many useful reactions are not accessible …
biocatalysts in organic synthesis. However, many useful reactions are not accessible …
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex
Y Huang, Z Wu, M Riwanto, S Gao… - The Journal of …, 2013 - Am Soc Clin Investig
Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein–
associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress …
associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress …
The structure and function of paraoxonase-1 and its comparison to paraoxonase-2 and-3
A Taler-Verčič, M Goličnik, A Bavec - Molecules, 2020 - mdpi.com
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases
(PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and …
(PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and …
Advances and applications of chemical protective clothing system
Protection is obligatory for the safety of people in certain occupations where they might be
exposed to hazardous chemicals. This review provides an overview of chemical protective …
exposed to hazardous chemicals. This review provides an overview of chemical protective …
Enzyme promiscuity: engine of evolutionary innovation
C Pandya, JD Farelli, D Dunaway-Mariano… - Journal of Biological …, 2014 - ASBMB
Catalytic promiscuity and substrate ambiguity are keys to evolvability, which in turn is pivotal
to the successful acquisition of novel biological functions. Action on multiple substrates …
to the successful acquisition of novel biological functions. Action on multiple substrates …
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium‐
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …