Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Autophagy is considered as an important mechanism for maintaining homeostasis and
responsible for the degradation of superfluous or potentially toxic components and …

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal …

The review summarizes data of recent experimental studies on spinal microglia, the least
explored cells of the spinal cord. It focuses on the origin and function of microglia in …

Objective This manuscript aimed to provide a comprehensive overview of the physiological,
molecular, and cellular mechanisms triggered by reactive astrocytes (RA) in the context of …

Although a couple of studies have reported that mutant superoxide dismutase 1 (SOD1), one
of the causative genes of familial amyotrophic lateral, interacts physically with lysyl-tRNA …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results
in death within 2–5 years of diagnosis. Respiratory failure is the most common cause of …

Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is
characterized by progressive motor neuron degeneration, leading to widespread weakness …

Microglia cells are the resident immune cells of the central nervous system. They act as the
first-line immune guardians of nervous tissue and central drivers of neuroinflammation. Any …