Long-read sequencing (LRS) technologies have provided extremely powerful tools to
explore genomes. While in the early years these methods suffered technical limitations, they …

DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark
contributing to gene expression regulation. DNA methylation patterns are specific to tissue …

Central nervous system tumours represent one of the most lethal cancer types, particularly
among children. Primary treatment includes neurosurgical resection of the tumour, in which …

Abstract The Oxford Nanopore (ONT) platform provides portable and rapid genome
sequencing, and its ability to natively profile DNA methylation without complex sample …

Background Third-generation nanopore sequencers offer selective sequencing or “Read
Until” that allows genomic reads to be analyzed in real time and abandoned halfway if not …

Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer
patients. Conventional short‐read sequencing lacks deployability and speed and can be …

Epigenetic changes in DNA methylation contribute to the development of many diseases,
including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and …

Tumor classification has evolved over the last decades with technical progress contributing
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …

Abstract Oxford Nanopore Technologies sequencing, also referred to as Nanopore
sequencing, stands at the forefront of a revolution in clinical genetics, offering the potential …

Background DNA methylation-based tumor classification allows an enhanced distinction into
subgroups of glioblastoma. However, the clinical benefit of DNA methylation-based …