The hepatitis B virus interactome: a comprehensive overview
E Van Damme, J Vanhove, B Severyn… - Frontiers in …, 2021 - frontiersin.org
Despite the availability of a prophylactic vaccine, chronic hepatitis B (CHB) caused by the
hepatitis B virus (HBV) is a major health problem affecting an estimated 292 million people …
hepatitis B virus (HBV) is a major health problem affecting an estimated 292 million people …
The current status and future directions of hepatitis B antiviral drug discovery
Introduction: The current standard care of chronic hepatitis B fails to induce a durable off-
drug control of hepatitis B virus (HBV) replication in the majority of treated patients. The …
drug control of hepatitis B virus (HBV) replication in the majority of treated patients. The …
5-Substituted pyridine-2, 4-dicarboxylate derivatives have potential for selective inhibition of human jumonji-C domain-containing protein 5
L Brewitz, Y Nakashima, SK Piasecka… - Journal of Medicinal …, 2023 - ACS Publications
Jumonji-C domain-containing protein 5 (JMJD5) is a 2-oxoglutarate (2OG)-dependent
oxygenase that plays important roles in development, circadian rhythm, and cancer through …
oxygenase that plays important roles in development, circadian rhythm, and cancer through …
Dysregulated expression of the nuclear exosome targeting complex component Rbm7 in nonhematopoietic cells licenses the development of fibrosis
K Fukushima, T Satoh, F Sugihara, Y Sato, T Okamoto… - Immunity, 2020 - cell.com
Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing
atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined …
atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined …
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription
JJ Deng, KYE Kong, WW Gao, HMV Tang… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Hepatitis B virus (HBV) genome is organized into a minichromosome known as covalently
closed circular DNA (cccDNA), which serves as the template for all viral transcripts. SIRT1 is …
closed circular DNA (cccDNA), which serves as the template for all viral transcripts. SIRT1 is …
[PDF][PDF] RETRACTED: HBV-encoded miR-2 functions as an oncogene by downregulating TRIM35 but upregulating RAN in liver cancer cells
L Yao, Y Zhou, Z Sui, Y Zhang, Y Liu, H Xie, H Gao… - …, 2019 - thelancet.com
Lili Yao a, 1, Yadi Zhou a, 1, Zhenhua Sui a, 1, Yanling Zhang a, Yankun Liu b, Hong Xie a,
Huijie Gao a, Hongxia Fan a, Yi Zhang a, Min Liu a, Shengping Li c, Hua Tang a,⁎ a Tianjin …
Huijie Gao a, Hongxia Fan a, Yi Zhang a, Min Liu a, Shengping Li c, Hua Tang a,⁎ a Tianjin …
[HTML][HTML] JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication
X Kong, Z Liu, R Zhang, R Liang, Y Zhang, L Yu… - JHEP Reports, 2023 - Elsevier
Background & Aims HBV infection is a global health burden. Covalently closed circular DNA
(cccDNA) transcriptional regulation is a major cause of poor cure rates of chronic hepatitis B …
(cccDNA) transcriptional regulation is a major cause of poor cure rates of chronic hepatitis B …
Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication
A Ariffianto, L Deng, T Abe, C Matsui, M Ito… - Journal of …, 2023 - Am Soc Microbiol
Hepatitis B virus (HBV) infection promotes reactive oxygen species production while
paradoxically inducing the expression of antioxidant enzymes. HBV-induced disorders of …
paradoxically inducing the expression of antioxidant enzymes. HBV-induced disorders of …
Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma
Y Mano, S Yoshio, H Shoji, S Tomonari, Y Aoki… - Journal of …, 2019 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) are essential constituents of
cancer-supportive microenvironments. The high incidence of hepatocellular carcinoma …
cancer-supportive microenvironments. The high incidence of hepatocellular carcinoma …
The JMJD family histone demethylases in crosstalk between inflammation and cancer
J Yang, Y Hu, B Zhang, X Liang, X Li - Frontiers in immunology, 2022 - frontiersin.org
Inflammation has emerged as a key player in regulating cancer initiation, progression, and
therapeutics, acting as a double edged sword either facilitating cancer progression and …
therapeutics, acting as a double edged sword either facilitating cancer progression and …