The genetics and typical traits of thoracic aortic aneurysm and dissection

J Rodrigues Bento, J Meester, I Luyckx… - Annual review of …, 2022 - annualreviews.org
Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

Genetics of thoracic aortic aneurysm: at the crossroad of transforming growth factor-β signaling and vascular smooth muscle cell contractility

E Gillis, L Van Laer, BL Loeys - Circulation research, 2013 - Am Heart Assoc
Aortic aneurysm, including both abdominal aortic aneurysm and thoracic aortic aneurysm, is
the cause of death of 1% to 2% of the Western population. This review focuses only on …

Spatially resolved transcriptome profiling in model plant species

S Giacomello, F Salmén, BK Terebieniec, S Vickovic… - Nature plants, 2017 - nature.com
Understanding complex biological systems requires functional characterization of
specialized tissue domains. However, existing strategies for generating and analysing high …

Aortic cellular diversity and quantitative genome-wide association study trait prioritization through single-nuclear RNA sequencing of the aneurysmal human aorta

EL Chou, M Chaffin, B Simonson… - … and Vascular Biology, 2022 - Am Heart Assoc
Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …

The human skeletal muscle transcriptome: sex differences, alternative splicing, and tissue homogeneity assessed with RNA sequencing

ME Lindholm, M Huss, BW Solnestam… - The FASEB …, 2014 - Wiley Online Library
Human skeletal muscle health is important for quality of life and several chronic diseases,
including type II diabetes, heart disease, and cancer. Skeletal muscle is a tissue widely used …

Biomechanical properties of the thoracic aneurysmal wall: differences between bicuspid aortic valve and tricuspid aortic valve patients

C Forsell, HM Björck, P Eriksson… - The Annals of thoracic …, 2014 - Elsevier
Background The prevalence for thoracic aortic aneurysms (TAAs) is significantly increased
in patients with a bicuspid aortic valve (BAV) compared with patients who have a normal …

The impact of endurance training on human skeletal muscle memory, global isoform expression and novel transcripts

ME Lindholm, S Giacomello, B Werne Solnestam… - PLoS …, 2016 - journals.plos.org
Regularly performed endurance training has many beneficial effects on health and skeletal
muscle function, and can be used to prevent and treat common diseases eg cardiovascular …

Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves

S Maleki, S Kjellqvist, V Paloschi, J Magné… - Scientific reports, 2016 - nature.com
Individuals with a bicuspid aortic valve (BAV) are at significantly higher risk of developing
aortic complications than individuals with tricuspid aortic valves (TAV) and defective …

Phenotypic and functional changes of endothelial and smooth muscle cells in thoracic aortic aneurysms

A Malashicheva, D Kostina, A Kostina… - … journal of vascular …, 2016 - Wiley Online Library
Thoracic aortic aneurysm develops as a result of complex series of events that alter the
cellular structure and the composition of the extracellular matrix of the aortic wall. The …

Proteomic and Transcriptomic Analyses of Fecundity in the Brown Planthopper Nilaparvata lugens (Stål)

Y Zhai, J Zhang, Z Sun, X Dong, Y He… - Journal of proteome …, 2013 - ACS Publications
As an r-strategy insect species, the brown planthopper (BPH) Nilaparvata lugens (Stål) is a
serious pest of rice crops in the temperate and tropical regions of Asia and Australia, which …