Generating mature, differentiated, adult lung cells from pluripotent cells, such as induced
pluripotent stem cells and embryonic stem cells, offers the hope of both generating disease …

The glucocorticoid receptor (GR) belongs to the steroid hormone receptor subclass of
nuclear receptors and controls physiological processes through activation and repression of …

Lung alveoli, which are unique to air-breathing organisms, have been challenging to
generate from pluripotent stem cells (PSCs) in part because there are limited model systems …

The ability to generate lung and airway epithelial cells from human pluripotent stem cells
(hPSCs) would have applications in regenerative medicine, modeling of lung disease, drug …

Alveolar epithelial type II cells (AEC2s) are the facultative progenitors of lung alveoli and
serve as the surfactant-producing cells of air-breathing organisms. Although primary human …

The stable expansion of tissue-specific stem cells in vitro has contributed to research on
several organs. Alveolar epithelial type II (AT2) cells function as tissue stem cells in the lung …

No methods for isolating induced alveolar epithelial progenitor cells (AEPCs) from human
embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been …

Summary Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give
rise to the entire postnatal lung and thyroid epithelium, but little is known about these cells …

It has been postulated that during human fetal development, all cells of the lung epithelium
derive from embryonic, endodermal, NK2 homeobox 1–expressing (NKX2-1+) precursor …

Lung and airway epithelial cells generated in vitro from human pluripotent stem cells
(hPSCs) have applications in regenerative medicine, modeling of lung disease, drug …