Peripheral biomarkers of treatment-resistant schizophrenia: Genetic, inflammation and stress perspectives

S Jiao, T Cao, H Cai - Frontiers in Pharmacology, 2022 - frontiersin.org
Treatment-resistant schizophrenia (TRS) often results in severe disability and functional
impairment. Currently, the diagnosis of TRS is largely exclusionary and emphasizes the …

Antipsychotic drug—Aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms

A Stelmach, K Guzek, A Rożnowska, I Najbar… - Pharmacological …, 2023 - Springer
Second-generation antipsychotics are widely used for the treatment of schizophrenia.
Aripiprazole (ARI) is classified as a third-generation antipsychotic drug with a high affinity for …

Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis

D Taylor, K Vallianatou, E Whiskey, O Dzahini… - Schizophrenia, 2022 - nature.com
The wider use of clozapine is limited by the risk of agranulocytosis and the associated
requirement for monitoring of neutrophil counts. We searched local electronic patient …

Clozapine induces an acute proinflammatory response that is attenuated by inhibition of inflammasome signaling: implications for idiosyncratic drug-induced …

SC Sernoskie, AR Lobach, R Kato, A Jee… - Toxicological …, 2022 - academic.oup.com
Although clozapine is a highly efficacious schizophrenia treatment, it is under-prescribed
due to the risk of idiosyncratic drug-induced agranulocytosis (IDIAG). Clinical data indicate …

[HTML][HTML] Clozapine prescribing barriers in the management of treatment-resistant schizophrenia: a systematic review

AI Baig, S Bazargan-Hejazi, G Ebrahim… - Medicine, 2021 - journals.lww.com
Background: Treatment-resistant schizophrenia is prevalent and difficult to manage, as
patients fail multiple antipsychotic trials before being considered as treatment-resistant …

The role of myeloperoxidase in clozapine-induced inflammation: a mechanistic update for idiosyncratic drug-induced agranulocytosis

SC Sernoskie, A Jee, J Uetrecht - International Journal of Molecular …, 2023 - mdpi.com
The risk of idiosyncratic drug-induced agranulocytosis (IDIAG) markedly constrains the use
of clozapine, a neuroleptic with unparalleled efficacy. Most clozapine patients experience an …

COVID-19 vaccines and the virus: impact on drug metabolism and pharmacokinetics

ER McColl, MA Croyle, WC Zamboni, WG Honer… - Drug Metabolism and …, 2023 - ASPET
This article reports on an American Society of Pharmacology and Therapeutics, Division of
Drug Metabolism and Disposition symposium held at Experimental Biology on April 2, 2022 …

[HTML][HTML] The effect of clozapine on immune-related biomarkers in schizophrenia patients

L Shao, Y Li, ZY Yuan, XY Guo, GJ Zeng, JP Liu - Brain Research Bulletin, 2024 - Elsevier
Globally, schizophrenia is one of the main causes of disability. Approximately 1% of the
general population suffers from schizophrenia, and 30% of cases are unresponsive to …

[HTML][HTML] Early neutrophil trajectory following clozapine may predict clozapine response–Results from an observational study using electronic health records

R Jones, I Morales-Munoz, A Shields… - Brain, Behavior, and …, 2023 - Elsevier
Background Clozapine has unique effectiveness in treatment-resistant schizophrenia and is
known to cause immunological side-effects. A transient spike in neutrophils commonly …

Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia

S Takase, J Liao, Y Liu, R Tanaka, Y Miyagawa… - European Journal of …, 2022 - Elsevier
Current antipsychotics used to treat schizophrenia have associated problems, including
serious side effects and treatment resistance. We recently identified a significant association …